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MedChemExpress
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pi3k inhibitor - by Bioz Stars,
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PKI-402(Cat No.:I000614)is a potent, small-molecule inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR), targeting key nodes of the PI3K/AKT/mTOR signaling pathway. By dual inhibition, PKI-402 suppresses tumor cell growth, survival, and proliferation
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Selleck Chemicals
pki 402 ![]() Pki 402, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/pki+402/PKI-402/pmc07854178-84-17-20 Average 93 stars, based on 1 article reviews
pki 402 - by Bioz Stars,
2026-08
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GlpBio Technology Inc
pi3k-agonist 740y-p ![]() Pi3k Agonist 740y P, supplied by GlpBio Technology Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/pki+402/pki+402+inhibitor+of+pi3k+mtor/pm40089548-163-22-24 Average 90 stars, based on 1 article reviews
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2026-08
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MultiTarget Pharmaceuticals
pki-402 ![]() Pki 402, supplied by MultiTarget Pharmaceuticals, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/pki+402/pki+402/pmc11126846-152-14-11 Average 90 stars, based on 1 article reviews
pki-402 - by Bioz Stars,
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PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM, respectively; also potent to PI3Kα mutants E545K and H1047R.
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PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and mammalian target of rapamycin (mTOR; IC(50) versus PI3K-alpha = 2 nmol/L). PKI-402 inhibited growth of human tumor
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Image Search Results
Journal: Molecules and Cells
Article Title: Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids
doi: 10.14348/molcells.2020.0212
Figure Lengend Snippet: (A) Expression levels of HYOU1 in NSCLC cells (NCI-H460 and H1299) treated with 0.1 μM or 1 μM of an mTOR inhibitor (Torin2 or WYE-125132) or a PI3K inhibitor (GDC0032 or PKI-402). (B) Expression levels of HYOU1 and mTOR in NSCLC cells (NCI-H460 and H1299) transfected with nonspecific siRNA (siCont), HYOU1 siRNA (siHYOU1), or mTOR siRNA (simTOR). The data shown are the mean ± SD from three independent experiments; * P < 0.05 compared to the control group.
Article Snippet: The cells were treated with 0.1 or 1 μM mTOR inhibitors, Torin2, WYE-125132, and PI3K inhibitors, GDC0032,
Techniques: Expressing, Transfection